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Dutch
Neuroscience Meeting

Dutch
Neuroscience Meeting

Online • 9-11 June 2021

Online
9-11 June 2021

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Illustrated Programme

 
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  • Wednesday, 9 June
  • Thursday, 10 June
  • Friday, 11 June
  • 12:30 General remarks and opening by Chair

    13:00 Plenary Session: Keynote Lecture

    Session 1: Keynote Lecture

    Chair: Harm Krugers (Amsterdam)


    Regina Marie Sullivan
    New York, NY, USA


    Neurobiology of infant attachment: Fear

    14:00 Coffee break - posters

    14:30 Parallel Sessions A

    Session 2: Regulators of the memory engram

    Chairs: Marloes Henckens (Nijmegen) & Harm Krugers (Amsterdam)

    One of the outstanding fundamental questions in modern neuroscience is how and where memory is physically stored in the brain. Recent development of memory engram technologies now allows for the identification and subsequent manipulation of components of specific memory engrams in particular brain regions. Cell ensembles recruited into the engram have been shown to be both sufficient and necessary for memory recall. Recent research has employed this technology to probe fundamental questions of memory consolidation, differentiating between mechanisms of memory retrieval from the true neurobiology of memory storage. A better working knowledge of the processes that are involved in encoding, consolidation and retrieval of specific memories could shed light on diseases that have memory-related alterations as one of their core hallmarks, including stress-related disorders like post-traumatic stress disorder (PTSD). Considering the importance of, and the recent increase in studies revolving around the memory engram, we propose to host a session covering the latest research in this field.


    Magdalena Sauvage
    Magdeburg, Germany


    Michel van den Oever
    Amsterdam


    Kübra Gülmez Karaca
    Nijmegen


    Marloes Henckens
    Nijmegen


    Sylvie Lesuis
    Toronto, Canada


    Session 3: Unraveling the biological mechanisms of aggressive behavior using complementary translational models

    Chairs: Mandy Meijer (Lausanne, Switzerland) & Barbara Franke (Nijmegen)

    Destructive and maladaptive behavior causes a huge burden on society, families and individuals. Aggressive behavior is associated with neurodevelopmental disorders, and so far there are no effective interventions. This is mainly due to a limited understanding of underlying mechanisms, and integration of different approaches, including model systems, new paradigms for human studies, and improved gene x environment analyses seem promising towards improving this knowledge. This session highlights the need for multidisciplinary research and exemplifies the successful use of complementary models.


    João Rodrigues
    Lausanne, Switzerland


    Nina Roth Mota
    Nijmegen


    Mandy Meijer
    Lausanne, Switzerland


    Jenny van Dongen
    Amsterdam


    Fiona Hagenbeek
    Amsterdam


    Session 4: Capture brain diseases on a chip

    Chairs: Svetlana Pasteuning-Vuhman (Amsterdam) & Nael Nadif Kasri (Nijmegen)

    Advances in microfluidic technology and stem cell biology enable the creation of a small functional unit of the brain or spinal cord such as blood brain barrier or neuromuscular unit in 3D. This state-of-the-art technology is very promising to better recapture physiologically relevant disease pathology of a patient, which will facilitate translation of preclinical research to clinics. While this technology is brand new, it is expected to progressively increase our capacity in discovery of new therapies and improve our understanding about underlying disease mechanisms. More importantly, combined with the iPSCs (induced pluripotent stem cells), a patient-specific model can be generated, providing future possibilities of a development towards personalized therapies for brain diseases. This session will give an overview of this technology and its ability to model a variety of neurological diseases such as Amyotrophic Lateral Sclerosis, Epilepsy, Migraine,and Hypoxia.


    Tatsuya Osaki
    Tokyo, Japan


    Monica Frega
    Enschede


    Eline van Hugte
    Nijmegen


    Xandor Spijkers
    Utrecht


    Jean‑Philippe Frimat
    Leiden


    Session 5: Transcranial magnetic stimulation and neuroscience: converging evidence from neuroimaging

    Chairs: Branislava Ćurčić-Blake (Groningen) & Alexander Sack (Maastricht)

    Transcranial magnetic stimulation (TMS) is increasingly being used for non-invasive brain stimulation in psychiatry and neurology. Interest in TMS has steadily increased over the years because of its potential to address more precise targets. However, the field is in need of more evidence regarding the neural changes relevant for TMS and/or induced by TMS. Combining different modalities by applying concurrent TMS, EEG and fMRI is one innovative approach that will be highlighted in this symposium. Other approaches involve measuring the effects of theta-burst TMS by fMRI pre- and post-treatment; attempting to enhance TMS effects using priming with tDCS; investigating brain connectivity using TMS and fNIRS, and using EEG for predicting TMS treatment responses in depressed patients. This symposium will present several novel developments in non-invasive brain stimulation technique for revealing the underlying mechanisms and for improving treatment efficacy in neuropsychiatric disorders.


    Marie‑Anne Vanderhasselt
    Ghent, Belgium


    Alexander Sack
    Maastricht


    André Aleman
    Groningen


    Dennis Schutter
    Utrecht


    Branislava Ćurčić‑Blake
    Groningen


    Session 6: Microglia in health and disease from rodents to humans

    Chairs: Kitty Reemst & Aniko Korosi (Amsterdam)

    Microglia are the resident immune cells of the CNS. They are plastic cells that can quickly respond to environmental cues by shifts in their phenotype and functions. There is increasing evidence that microglia are crucial for proper development and adult functioning of the CNS. Emerging data indeed indicate that stress and disease state influence microglia phenotypes, and that these changes are key for the stress or disease induced alterations in brain structure and function. Within this session, we will elaborate on microglia development, phenotypes and microglia-neurons interactions in relation to health and disease, using rodent models, human iPSC derived organoids and post-mortem human tissue.


    Eric Wohleb
    Cincinnati, OH, USA


    Chun‑Xia Yi
    Amsterdam


    Janssen Kotah
    Amsterdam


    Laura Kracht
    Groningen


    Tijana Ljubikj
    Utrecht


    16:00 Coffee-posters-actual poster presenting time

    Session 7: Poster session 1

    17:00 Plenary Session

    Session 8: Workshop on ethics animal research

    20:00 Drinks/Quizzes

  • 12:30 Parallel Sessions B

    Session 9: Assessing human stress reactivity in the lab and in day to day life

    Chairs: Judith van Leeuwen (Nijmegen) & Femke Lamers (Amsterdam)

    A large body of research has linked stressful life events to the development of many psychiatric disorders. The effects of stress on the brain are therefore extensively studied in both healthy controls and psychiatric patients. Indeed, differences between the groups in neural responses to stress are observed. However, it remains unclear whether responses to laboratory stressors accurately reflect how an individual behaves in a more natural setting. One way to better capture the day to day experiences is to examine thoughts and affect using smartphone-based surveys. Thanks to these ecological momentary assessments, we now have a better understanding of how people behave and feel in their daily lives. However, substantial gaps remain in our knowledge on how to translate the data from one line of research to the other. How can we use our imaging data to better understand how people feel in their daily life and vice versa? Do we need to change our questionnaires to better match our imaging tasks? Do our imaging tasks have ecological validity? How to address the time-dependent effects that stress has on the brain in our EMA questionnaires? Our speakers from both research lines will try to address these questions.


    Thomas Vaessen
    Leuven, Belgium


    Rayyan Toutounji
    Nijmegen


    Sanne Booij
    Groningen


    David Rosenbaum
    Tuebingen, Germany


    Femke Lamers
    Amsterdam


    Session 10: In search for therapeutic targets for treatment of Parkinson’s Disease

    Chairs: Willemieke Kouwenhoven (Montreal, Canada) & Lars van der Heide (Amsterdam)

    Parkinson’s Disease (PD) is the second most common neurodegenerative disease after Alzheimer’s Disease. Although Levodopa is no cure for PD, it has been the golden standard in treating the disease since the 1960s. It is time for new therapy. Current research focusses on a better understanding of the PD pathology, allowing for the discovery on novel therapy targets. In this session speakers will discuss their perspective on the molecular and neurochemical changes that occur in the brain and the body during Parkinson’s Disease (PD) and how these changes form targets for existing therapies and posses a potential for the development of novel therapies. This is an interesting session which will cover the fundamental (embryonic) development of dopamine neurons, in vivo PD models, in vitro studies with patient material and finally clinical studies with PD patients.


    Lars van der Heide
    Amsterdam


    Willemieke Kouwenhoven
    Montreal, Canada


    Pier G. Mastroberardino
    Rotterdam


    Rob de Bie
    Amsterdam


    Wilma van de Berg
    Amsterdam


    Session 11: The axon initial segment: from nanoscale organization to human pathology

    Chairs: Amélie Freal (Amsterdam) & Paul Jenkins (Ann Arbor, MI, USA)

    We know for a decade that the axon initial segment (AIS) is crucial for initiating all action potentials. The molecular complexity of this compartment is, however becoming only recently appreciated. In particular resolving the nanoscale organization of the AIS and linking it to the neuron physiology remains a challenge. Recent advances in microscopy, cell biology, high-resolution electrophysiology and the development of new models now makes it possible to deepen our understanding of the AIS. The aim of this session is to bridge cell biology and AIS physiology in health and disease. By bringing together expert labs in the field, we will highlight how the use of innovative tools, approaches and study models are currently revealing exciting new insights into the AIS biology. Notably, we will show how iPSC neurons derived from patients allow to address the pathology of diseases implicating AIS proteins such as schizophrenia or bipolar disorders. We will emphasize how super-resolution imaging of endogenous AIS proteins and high-resolution electrophysiology greatly enhance our knowledge on AIS physiology. Paul Jenkins will show how his lab investigates human mutations of AIS proteins from genetics to pathology in mouse models.


    Paul Jenkins
    Ann Arbor, MI, USA


    Elly Lewerissa
    Nijmegen


    Amélie Freal
    Amsterdam


    Feline Lindhout
    Utrecht


    Naomi Hanemaaijer
    Amsterdam


    Session 12: Open (Neuro)science: facilitating transparency, collaboration, and reliability in human neuroimaging research

    Chairs: Zsuzsika Sjoerds & Lotte van Dillen (Leiden)

    Currently we see that scientific reliability in multiple disciplines is under scrutiny, as several high impact studies cannot be reproduced, partly due to a lack of power and transparency in methodology and analyses. This ‘replication crisis’ has been recognized in the psychological sciences, but now also receives increasing attention in the (cognitive) neurosciences, were advanced neuroimaging techniques offer the chance to obtain large-scale brain data. In response to this replication crisis, a scientific reform, both bottom-up and top-down, that advocates good research practices and Open Science is spreading from the social sciences across the entire scientific field. Open Science makes research more transparent, efficient, and reproducible, overcoming problems that lead to the unreliability of research output, and will likely be part of the workflow for many, if not all, scientists in the near future. It is therefore important for scientists to stay informed about new developments and best practices. In this symposium we gather scientists who apply Open Science practices in their neuroscientific research, and who develop and implement Open Science tools that can be shared with other scientists in the field to freely use.


    Remi Gau
    Louvain, Belgium


    Eduard Klapwijk
    Rotterdam


    Dorien Huijser
    Leiden


    Stephan Heunis
    Jülich, Germany


    Floor van Meer
    Leiden


    Session 13: Human brain evolution, a multidisciplinary perspective

    Chairs: Lianne Scholtens & Roxana Kooijmans (Amsterdam)

    What makes us human? In recent evolution, the human brain has gone through a rapid expansion. As a result, the human brain has a large capacity for higher cognitive function and social behavior. The question of exactly what aspects of human brain organization have changed to facilitate these higher-order functions – and whether those changes may have potential implications for mental disorders – is currently a hot topic in the field.
    In recent years, Dutch neuroscientists have employed state-of-the art techniques ranging from brain organelles (Jacobs), high-resolution post-mortem MRI (Freches), connectivity changes with primate brain size (Ardesch), human adaptations in brain connectivity (van den Heuvel) and the study of social behaviors (Massen) to gain better understanding of the mechanisms underlying human brain evolution and its effect on current-day human brain (dis)function.
    Approaching the human brain from multiple neuroscientific perspectives, this parallel session will provide a broad overview of current topics in the study of human brain evolution, ranging from genetics and brain organelles to large-scale brain wiring, functional networks important for cognition and social behaviors.


    Frank Jacobs
    Amsterdam


    Martijn van den Heuvel
    Amsterdam


    Dirk Jan Ardesch
    Amsterdam


    Guilherme Blazquez Freches
    Nijmegen


    Jorg Massen
    Utrecht


    14:00 Coffee break - posters

    14:30 Plenary Session

    Session 14: Career & Industry

    Chairs: Rudy Schreiber & Jos Prickaerts (Maastricht)


    Mark Millan
    Glasgow, United Kingdom


    A critical look at progress and prospects for personalised-precision medicine for neurodegenerative disorders

    15:30 Coffee-posters-actual poster presenting time

    Session 15: Poster session 2

    16:30 Parallel Sessions C

    Session 16: Immunometabolism in the brain in health and disease

    Chairs: Merel Rijnsburger & Chun-Xia Yi (Amsterdam)

    Over the past decade, the immunometabolism of the brains’ glial cells has become one of the most exciting areas of translational research. Metabolic processes regulate glia responses in healthy individuals as well as during neuro-inflammatory diseases. On cellular, tissue, and organismal levels, emerging evidence demonstrates a complex interplay between metabolism and inflammation that must be precisely regulated to support biological functions. Moreover, immune responses are shaped not only by host metabolites, but also by metabolites derived from the microbiota and infectious agents. The glial cells of the CNS, in particular microglia and astrocytes are important contributors to neuro-inflammation, that is evidently present in several diseases of the CNS including obesity, Alzheimer’s disease and multiple sclerosis (MS). Several disease modifying treatments for neuro-inflammation have been shown to interfere with metabolic pathways in different cell types. Thus, metabolic reprogramming - driving glia towards anti-inflammatory functions by manipulation of their metabolic pathways - may provide new therapeutic opportunities to control excessive inflammation in brain disorders.


    Joshua Thaler
    Seattle, WA, USA


    Irina Milanova
    Amsterdam


    Felipe Correa da Silva
    Amsterdam


    Emma Gerrits
    Groningen


    Merel Rijnsburger
    Amsterdam


    Session 17: The cerebellum as the spider in the web: cerebello-cortical interactions supporting cognition and complex behaviors

    Chairs: Aleksandra Badura (Rotterdam) & Tomas Knapen (Amsterdam)

    Polysynaptic connections between cerebellum and neocortex constitute one of the largest neural systems in the human brain. These cortico-cerebellar loops provide the anatomical backbone for cerebellar contributions to a wide array of functional domains outside of motor control, such as working memory, language, social cognition, and cognitive control. Recent advances in basic circuit mapping and functional imaging of cerebello-cerebral connections have revolutionized clinical diagnoses of neurodevelopmental (e.g. autism spectrum disorder) and neurodegenerative disorders (e.g. ataxias). The goal of this parallel session is to provide a comprehensive overview of the field of cerebellar imaging in humans and experiments in animal models during complex tasks, highlighting the most exciting developments. We propose to organise a session where scientists who use different models discuss their contribution to the understanding of the role of the cerebellum in cognition. Specifically, we will invite two PIs who study human cerebellum using fMRI techniques, two postdoctoral fellows who work with murine models and a PhD student who investigates the cerebelllo-cortical networks in non-human primates.


    Dennis Schutter
    Utrecht


    Tomas Knapen
    Amsterdam


    Ines Serra
    Rotterdam


    Catarina Osório
    Rotterdam


    Nico Flierman
    Amsterdam


    Session 18: Non-coding RNAs as therapeutic targets and biomarkers for brain disease

    Chairs: Jeroen Pasterkamp (Utrecht) & Noora Puhakka (Kuopio, Finland)

    Current therapies for many of the neurological disorders are insufficiently effective and there is an unmet need for new biomarkers to predict disease stage and progression. With recent technological advances in exploring the transcriptome, several new classes of non-coding RNAs have been discovered. We will discuss the role of these different classes of non-coding RNAs as therapeutic targets and biomarkers including circular RNAs (circRNA), microRNAs (miRNAs) and transfer RNAs (tRNAs). The speakers in our session investigate the functional role of non-coding RNAs in normal brain and various neurological diseases (AD, TBI and Epilepsy) using state-of-the-art molecular cell biological approaches, patient-derived data and pre-clinical models.


    Thomas Birkballe Hansen
    Aarhus, Denmark


    Hannah Walgrave
    Leuven, Belgium


    Erwin van Vliet
    Amsterdam


    Vamshi Vangoor
    Utrecht


    Noora Puhakka
    Kuopio, Finland


    Session 19: Organelle dynamics in neuronal development and plasticity

    Chairs: Christian Lohmann (Amsterdam) & Ginny Farías (Utrecht)

    The functional wiring of the brain and its life-long adaptations are fundamental for our lives. Both the formation and plasticity of synaptic connections have been investigated mostly in light of neuronal growth, receptor delivery and turnover; however recent discoveries showed that intracellular organelles and their dynamics are very important for the development, plasticity and health of synaptic connections as well. It has been known for some time that these organelles, such as mitochondria, endosomes and the endoplasmic reticulum, provide energy, buffer calcium and deliver synaptic macromolecular components; however, only now it becomes clear how organelles, their specific localization, structural dynamics and interactions contribute to neuronal development and plasticity. These breakthrough observations have been made possible in particular by the invention of novel live-cell imaging techniques, including super resolution microscopy.


    Jean‑Michel Cioni
    Milan, Italy


    Max Koppers
    Utrecht


    Ginny Farías
    Utrecht


    Koen Kole
    Amsterdam


    Christian Lohmann
    Amsterdam


    Session 20: The human histaminergic system in neuropsychiatric disorders: from animal models to clinical treatment

    Chairs: Gert Jan Lammers & Ling Shan (Leiden)

    Both the European Medicines Agency (EMA) and the United States Food and Drug Administration (FDA) approved an H3R-antagonist/inverse agonist compound for the treatment of excessive sleepiness in narcolepsy. This compound currently is also advancing into clinical trials as a potential treatment for Parkinson’s disease and Alzheimer’s disease. It is known that the neuronal histaminergic system is involved in a number of basic physiological functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, attention, and learning and memory, all of which tend to be severely affected in neuropsychiatric disorders. The current parallel session presents the alterations in the histamine system, mainly from speakers’ own studies. Changes in the histamine system in neuropsychiatric disorders are discussed, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, depression and narcolepsy.


    William Wisden
    London, United Kingdom


    Ling Shan
    Leiden


    Gert Jan Lammers
    Leiden


    Chen Zhong
    Hangzhou, China


    18:00 Coffee break - posters

    18:30 Plenary Session

    Session 21: Prizes

  • 12:30 Parallel Sessions D

    Session 22: Nutritional approaches to the prevention and treatment of psychiatric disorders

    Chairs: Veronica Begni & Aniko Korosi (Amsterdam)

    Exciting developing evidence indicates powerful effects of nutrients on the brain. This offers a new therapeutic perspective. In this symposium, we will discuss the role of nutrients in supporting optimal neurodevelopment and in prevention and treatment of a broad range of neurological disorders. We will discuss pre-clinical and clinical evidence of the potential relevance of nutritional interventions as (add-on) strategy to treat these disorders.


    Teresa Reyes
    Cincinnati, OH, USA


    Veronica Begni
    Amsterdam


    Gijs Kooij
    Amsterdam


    Esther Aarts
    Nijmegen


    Hannah Juncker
    Amsterdam


    Session 23: Trends in neuromodulation

    Chairs: Sarah-Anna Hescham & Ali Jahanshahi (Maastricht)

    The field of neuromodulation is active, growing and innovative. It has revolutionized the treatment of various neurologic and psychiatric disorders within the past three decades. Advances in neuromodulation seem to be linked to the fact that systemic drug based approaches have not delivered the breakthroughs that the field was looking for, mainly in the field of neuropsychiatric diseases. This led to a downscaling of central nervous system drug activities of major companies. In addition, our increased understanding of the neurobiology of brain disorders from studies in translational models paved the way for the clinical application of, for example, deep brain stimulation. That is why, deep brain stimulation is used in several neurological and psychiatric disorders. Lastly, technological advances in the field of fundamental neuroscience have enabled a more thorough understanding of neural macrocircuitries that play a role in various disorders. These circuitries are currently targeted by experimental neuromodulatory approaches. In this session we will provide a comprehensive perspective on the field of neuromodulation that substantively explores both the essential and innovative topics.


    Nir Grossman
    London, United Kingdom


    Myles McLaughlin
    Leuven, Belgium


    Jackson Boonstra
    Maastricht


    Tycho Hoogland
    Amsterdam


    Sarah‑Anna Hescham
    Maastricht


    Session 24: Probing and targeting cAMP: from local control of signaling nanodomains to cognitive function

    Chairs: Jos Prickaerts (Maastricht) & Tim Vanmierlo (Diepenbeek, Belgium)

    The cyclic nucleotide cAMP is a key regulator of cellular differentiation processes. This session aims to present the latest cutting-edge research on cAMP signaling directing CNS plasticity during various physiological as well as pathological conditions. Especially cAMP signaling and its importance in cognitive functions will be highlighted. Also recent advances in technologies, such as new mass spectrometric methods, imaging and structural biology, will be covered as they profoundly changed how these signaling pathways and their dynamics are examined. Until now, interventions focused mainly on directly manipulating the catalytic domain of enzymes involved in the synthesis or degradation of cAMP. Recently, novel avenues to target cAMP signaling are being explored, including protein-protein interactions and post-translational modifications which alter the activity of these enzymes and their interaction with stimulators, activators and inhibitors. Linked to this, also the role of cell-type specific compartmentalization of cAMP signaling will be discussed. It will be evident that the effects on brain plasticity (e.g. neurodegeneration, inflammation and myelination) and consequently cognition depend on cAMP signaling within the specific cell types (e.g. neuronal, microglial, oligodendrocytic). Finally, (epi)genetic control of cAMP signaling is also discussed. Thus we aim to recapitulate the progress being made in targeting localized cAMP signaling in different cell types to stimulate brain plasticity and cognition.


    George Baillie
    Glasgow, United Kingdom


    Ying Xu
    Buffalo, NY, USA


    Tim Vanmierlo
    Diepenbeek, Belgium


    Melissa Schepers
    Diepenbeek, Belgium


    Robbert Havekes
    Groningen


    Session 25: Brain injury and consequences for sleep and fatigue

    Chairs: Jessica Bruijel (Maastricht) & Christian Baumann (Zurich, Switzerland)

    There is increasing awareness for the importance of sleep for mental and physical health, in the last years. Sleep has been recognized as a transdiagnostic factor in a large variety of mental health problems. Research has shown a distinctive role of sleep in cognition, processing of emotions, and immune function. Recently it has been discovered that during sleep waste substances are removed from the brain. These findings raised attention for sleep complaints and fatigue among researchers of psychiatric, neurological and somatic disorders. In patients with acquired brain injury, sleep disturbances and fatigue were often neglected, even though these are the most prevalent and persisting consequences of brain injury. Research on the etiology, development and treatment of sleep disturbances and fatigue in brain injury patients is now growing. In addition, health care professionals are now developing new procedures to attend to these problems, with shifts towards long-term behavioral approaches instead of medication. This session will provide an overview of the relation between sleep and fatigue in patients with brain injury, and discuss possible treatment options by presenting results from recent studies.


    Christian Baumann
    Zurich, Switzerland


    Marthe Ford
    Wijk aan Zee


    Bert Lenaert
    Maastricht


    Louise Pilon
    Arnhem


    Jessica Bruijel
    Maastricht


    Session 26: Human induced pluripotent stem cell models for neuron-glia interaction studies

    Chairs: Anne-Marie van Dam & Vivi Heine (Amsterdam)

    Human brain disorders are a burden for patients, relatives and society. There is a major force to better understand the pathogenesis of those complex diseases to come to therapeutic targets to intervene in the disease process. Developments in the field of human induced pluripotent stem cells (iPSCs) have realized the production of various types of human brain cells from individuals. These include neurons, astrocytes, microglia and oligodendrocytes expressing the genetic make-up of a diseased or control subject. By using 2D, 3D or organoid cultures of human iPSC-derived brain cells, it is aimed to identify the effect of intrinsic, e.g. genetic, or extrinsic, e.g. inflammation, factors on the individual brain cells as well as on their interaction. In recent years iPSC-based model systems quickly advanced thereby gaining interest for implementation in a wide range of basic and translational studies.


    Anna Falk
    Stockholm, Sweden


    Bas Lendemeijer
    Rotterdam


    Massimiliano Caiazzo
    Utrecht


    Marloes Verkerke
    Utrecht


    Vivi Heine
    Amsterdam


    14:00 Coffee break - posters

    14:30 Parallel Sessions E

    Session 27: The neurochemistry of adaptive behavior: new insights from effort, pain, and stress

    Chairs: Dennis Hernaus (Maastricht) & Eliana Vassena (Nijmegen)

    Humans continuously adapt to unpredictable environments. This, among others, requires two core skills: learning (about which actions lead to good and bad outcomes), and motivation (to pursue good things and avoid bad things). While adaptive behavior is essential, its neurochemical underpinnings remain elusive. This symposium will provide novel mechanistic insights into the neurochemistry of adaptive behavior, integrating computational modeling, neuroimaging, and pharmacology. The presenters’ pre-clinical and human work reveals a central role for catecholamines and opioids in regulating adaptive decisions, with important implications for psychopathology.


    Sebastien Bouret
    Paris, France


    Dennis Hernaus
    Maastricht


    Massimo Silvetti
    Rome, Italy


    Marieke Jepma
    Amsterdam


    Henk van Steenbergen
    Leiden


    Session 28: Voltage imaging: an all-optical toolbox for direct readout of neural activity

    Chairs: Naomi Hanemaaijer (Amsterdam) & Daan Brinks (Delft)

    Voltage imaging is an emerging technology in the neurosciences because of its ability to detect single spikes and subthreshold membrane fluctuations bidirectionally. The past decade has shown that imaging membrane potentials in small neurites, such as spines or boutons, improved our understanding of synaptic signaling and action potential propagation. More recently, the imaging of voltage has received a surge of attention; the development and application of improved genetically encoded voltage indicators (GEVIs) has exploded and nowadays GEVIs record neural activity with submillisecond temporal resolution and with genetic specificity, both in vitro and in vivo. The all-optical toolbox for tracking brain activity, also encompassing techniques like light patterning and optogenetics, has rapidly expanded and is becoming established in multiple laboratories in the Netherlands. In this session we will bring together international and Dutch speakers working with voltage indicators to discuss the most recent developments of voltage imaging, from directed genetic engineering of probes to in vivo recordings delivering new insights into neural basis of behavior.


    Michael Hoppa
    Hanover, NH, USA


    Linlin Fan
    Stanford, CA, USA


    Daan Brinks
    Delft


    Xin Meng
    Delft


    Naomi Hanemaaijer
    Amsterdam


    Session 29: The immune system in neurological disorders

    Chairs: Jinte Middeldorp (Rijswijk) & Elga de Vries (Amsterdam)

    The neuropathology of CNS disorders such as Alzheimer’s disease and stroke are characterized by an aberrant functioning of the immune system. Yet, this neuro-immune interaction is not only involved in the onset, progression, and clinical manifestation of neurological diseases, but in some cases also plays a protective role in the pathogenesis of various brain disorders. A complex interplay of peripheral immune cells, the blood-brain barrier, and CNS resident immune and glial cells steers the destructive and regenerative capacity of the CNS. Elucidating the underlying mechanisms involved in this neuro-immune interplay is predicted to generate novel leads for future treatments. It is now well established that in several neurological disorders there is an imbalance or aberrant communication between both systems. In our proposed session the latest research on this imbalance will be discussed from both the peripheral and the CNS point of view, and the cross-talk between them. The diseases of focus will be Alzheimer’s disease, stroke and glioma, which all have different etiologies, but important inflammatory components, and a drastic need for novel therapies.


    Leila Akkari
    Amsterdam


    Anu Meerwaldt
    Utrecht


    Lynn van Olst
    Amsterdam


    Marianna Bugiani
    Amsterdam


    David Gate
    Stanford, CA, USA


    Session 30: Lipids in synaptic function and pathology

    Chairs: Yolanda Gutierrez (Utrecht) & Mark Verheijen (Amsterdam)

    Lipids play a fundamental role in a wide range of cellular processes and are the most abundant components of the brain. Specific lipid species such as cholesterol and phosphoinositides are enriched in synapses and have been directly implicated in the control of synapse development and synaptic plasticity. Particularly, dysregulation of lipid homeostasis perturbs synaptic function and is thought to underlie the neuronal pathology observed in diseases such as Niemann-Pick and Alzheimer’s diseases, further evidencing their relevance for synaptic transmission. With this proposal, we will feature key studies and working projects that are shifting the prevailing focus from proteins to lipids. They will provide a unique global perspective ranging from state-of-the-art techniques to gain insight into synaptic membrane composition, to the influence of lipid metabolism and diet on cognition and for the treatment of different neurodegenerative diseases. Overall, proposed lectures will encompass a multidisciplinary view that will cover all levels from fundamental to applied science, highlighting the key role of lipids in neuronal functioning.


    Maria Dolores Ledesma
    Madrid, Spain


    Rik van der Kant
    Amsterdam


    Kitty Reemst
    Amsterdam


    Yolanda Gutierrez
    Utrecht


    Mark Verheijen
    Amsterdam


    Session 31: Leveraging on translational prospective approaches to elucidate the biological signature of differential PTSD susceptibility

    Chairs: Mirjam van Zuiden (Amsterdam) & Marloes Henckens (Nijmegen)

    10-20% of trauma-exposed individuals develops posttraumatic stress disorder (PTSD). To develop effective preventive interventions for PTSD, it is pivotal to increase our understanding of neurobiological mechanisms underlying the differential susceptibility vs resiliency to PTSD by using translational prospective approaches. In this symposium we bring together recent findings of new experimental paradigms in rodents and humans with innovative clinical prospective approaches to share the latest developments in resilience research.


    Lotte Hilberdink
    Amsterdam


    Marloes Henckens
    Nijmegen


    Floris Klumpers
    Nijmegen


    Katharina Schultebraucks
    New York, NY, USA


    16:00 Coffee-posters-actual poster presenting time

    Session 32: Poster session 3

    17:00 Plenary Session

    Session 33: Keynote Lecture

    Chair: Mark Verheijen (Amsterdam)


    Baljit Khakh
    Los Angeles, CA, USA


    Unmasking astrocyte contributions to neural circuit function

    18:00 Closure DNM 21