12:30 Parallel Sessions D
Session 22: Nutritional approaches to the prevention and treatment of psychiatric disorders
Chairs: Veronica Begni & Aniko Korosi (Amsterdam)
Exciting developing evidence indicates powerful effects of nutrients on the brain. This offers a new therapeutic perspective. In this symposium, we will discuss the role of nutrients in supporting optimal neurodevelopment and in prevention and treatment of a broad range of neurological disorders. We will discuss pre-clinical and clinical evidence of the potential relevance of nutritional interventions as (add-on) strategy to treat these disorders.
Cincinnati, OH, USA
Session 23: Trends in neuromodulation
Chairs: Sarah-Anna Hescham & Ali Jahanshahi (Maastricht)
The field of neuromodulation is active, growing and innovative. It has revolutionized the treatment of various neurologic and psychiatric disorders within the past three decades. Advances in neuromodulation seem to be linked to the fact that systemic drug based approaches have not delivered the breakthroughs that the field was looking for, mainly in the field of neuropsychiatric diseases. This led to a downscaling of central nervous system drug activities of major companies. In addition, our increased understanding of the neurobiology of brain disorders from studies in translational models paved the way for the clinical application of, for example, deep brain stimulation. That is why, deep brain stimulation is used in several neurological and psychiatric disorders. Lastly, technological advances in the field of fundamental neuroscience have enabled a more thorough understanding of neural macrocircuitries that play a role in various disorders. These circuitries are currently targeted by experimental neuromodulatory approaches. In this session we will provide a comprehensive perspective on the field of neuromodulation that substantively explores both the essential and innovative topics.
London, United Kingdom
Session 24: Probing and targeting cAMP: from local control of signaling nanodomains to cognitive function
Chairs: Jos Prickaerts (Maastricht) & Tim Vanmierlo (Diepenbeek, Belgium)
The cyclic nucleotide cAMP is a key regulator of cellular differentiation processes. This session aims to present the latest cutting-edge research on cAMP signaling directing CNS plasticity during various physiological as well as pathological conditions. Especially cAMP signaling and its importance in cognitive functions will be highlighted. Also recent advances in technologies, such as new mass spectrometric methods, imaging and structural biology, will be covered as they profoundly changed how these signaling pathways and their dynamics are examined. Until now, interventions focused mainly on directly manipulating the catalytic domain of enzymes involved in the synthesis or degradation of cAMP. Recently, novel avenues to target cAMP signaling are being explored, including protein-protein interactions and post-translational modifications which alter the activity of these enzymes and their interaction with stimulators, activators and inhibitors. Linked to this, also the role of cell-type specific compartmentalization of cAMP signaling will be discussed. It will be evident that the effects on brain plasticity (e.g. neurodegeneration, inflammation and myelination) and consequently cognition depend on cAMP signaling within the specific cell types (e.g. neuronal, microglial, oligodendrocytic). Finally, (epi)genetic control of cAMP signaling is also discussed. Thus we aim to recapitulate the progress being made in targeting localized cAMP signaling in different cell types to stimulate brain plasticity and cognition.
Glasgow, United Kingdom
Buffalo, NY, USA
Session 25: Brain injury and consequences for sleep and fatigue
Chairs: Jessica Bruijel (Maastricht) & Christian Baumann (Zurich, Switzerland)
There is increasing awareness for the importance of sleep for mental and physical health, in the last years. Sleep has been recognized as a transdiagnostic factor in a large variety of mental health problems. Research has shown a distinctive role of sleep in cognition, processing of emotions, and immune function. Recently it has been discovered that during sleep waste substances are removed from the brain. These findings raised attention for sleep complaints and fatigue among researchers of psychiatric, neurological and somatic disorders. In patients with acquired brain injury, sleep disturbances and fatigue were often neglected, even though these are the most prevalent and persisting consequences of brain injury. Research on the etiology, development and treatment of sleep disturbances and fatigue in brain injury patients is now growing. In addition, health care professionals are now developing new procedures to attend to these problems, with shifts towards long-term behavioral approaches instead of medication. This session will provide an overview of the relation between sleep and fatigue in patients with brain injury, and discuss possible treatment options by presenting results from recent studies.
Wijk aan Zee
Session 26: Human induced pluripotent stem cell models for neuron-glia interaction studies
Chairs: Anne-Marie van Dam & Vivi Heine (Amsterdam)
Human brain disorders are a burden for patients, relatives and society. There is a major force to better understand the pathogenesis of those complex diseases to come to therapeutic targets to intervene in the disease process. Developments in the field of human induced pluripotent stem cells (iPSCs) have realized the production of various types of human brain cells from individuals. These include neurons, astrocytes, microglia and oligodendrocytes expressing the genetic make-up of a diseased or control subject. By using 2D, 3D or organoid cultures of human iPSC-derived brain cells, it is aimed to identify the effect of intrinsic, e.g. genetic, or extrinsic, e.g. inflammation, factors on the individual brain cells as well as on their interaction. In recent years iPSC-based model systems quickly advanced thereby gaining interest for implementation in a wide range of basic and translational studies.
14:00 Coffee break - posters
14:30 Parallel Sessions E
Session 27: The neurochemistry of adaptive behavior: new insights from effort, pain, and stress
Chairs: Dennis Hernaus (Maastricht) & Eliana Vassena (Nijmegen)
Humans continuously adapt to unpredictable environments. This, among others, requires two core skills: learning (about which actions lead to good and bad outcomes), and motivation (to pursue good things and avoid bad things). While adaptive behavior is essential, its neurochemical underpinnings remain elusive. This symposium will provide novel mechanistic insights into the neurochemistry of adaptive behavior, integrating computational modeling, neuroimaging, and pharmacology. The presenters’ pre-clinical and human work reveals a central role for catecholamines and opioids in regulating adaptive decisions, with important implications for psychopathology.
Henk van Steenbergen
Session 28: Voltage imaging: an all-optical toolbox for direct readout of neural activity
Chairs: Naomi Hanemaaijer (Amsterdam) & Daan Brinks (Delft)
Voltage imaging is an emerging technology in the neurosciences because of its ability to detect single spikes and subthreshold membrane fluctuations bidirectionally. The past decade has shown that imaging membrane potentials in small neurites, such as spines or boutons, improved our understanding of synaptic signaling and action potential propagation. More recently, the imaging of voltage has received a surge of attention; the development and application of improved genetically encoded voltage indicators (GEVIs) has exploded and nowadays GEVIs record neural activity with submillisecond temporal resolution and with genetic specificity, both in vitro and in vivo. The all-optical toolbox for tracking brain activity, also encompassing techniques like light patterning and optogenetics, has rapidly expanded and is becoming established in multiple laboratories in the Netherlands. In this session we will bring together international and Dutch speakers working with voltage indicators to discuss the most recent developments of voltage imaging, from directed genetic engineering of probes to in vivo recordings delivering new insights into neural basis of behavior.
Hanover, NH, USA
Stanford, CA, USA
Session 29: The immune system in neurological disorders
Chairs: Jinte Middeldorp (Rijswijk) & Elga de Vries (Amsterdam)
The neuropathology of CNS disorders such as Alzheimer’s disease and stroke are characterized by an aberrant functioning of the immune system. Yet, this neuro-immune interaction is not only involved in the onset, progression, and clinical manifestation of neurological diseases, but in some cases also plays a protective role in the pathogenesis of various brain disorders. A complex interplay of peripheral immune cells, the blood-brain barrier, and CNS resident immune and glial cells steers the destructive and regenerative capacity of the CNS. Elucidating the underlying mechanisms involved in this neuro-immune interplay is predicted to generate novel leads for future treatments.
It is now well established that in several neurological disorders there is an imbalance or aberrant communication between both systems. In our proposed session the latest research on this imbalance will be discussed from both the peripheral and the CNS point of view, and the cross-talk between them. The diseases of focus will be Alzheimer’s disease, stroke and glioma, which all have different etiologies, but important inflammatory components, and a drastic need for novel therapies.
Lynn van Olst
Stanford, CA, USA
Session 30: Lipids in synaptic function and pathology
Chairs: Yolanda Gutierrez (Utrecht) & Mark Verheijen (Amsterdam)
Lipids play a fundamental role in a wide range of cellular processes and are the most abundant components of the brain. Specific lipid species such as cholesterol and phosphoinositides are enriched in synapses and have been directly implicated in the control of synapse development and synaptic plasticity. Particularly, dysregulation of lipid homeostasis perturbs synaptic function and is thought to underlie the neuronal pathology observed in diseases such as Niemann-Pick and Alzheimer’s diseases, further evidencing their relevance for synaptic transmission. With this proposal, we will feature key studies and working projects that are shifting the prevailing focus from proteins to lipids. They will provide a unique global perspective ranging from state-of-the-art techniques to gain insight into synaptic membrane composition, to the influence of lipid metabolism and diet on cognition and for the treatment of different neurodegenerative diseases. Overall, proposed lectures will encompass a multidisciplinary view that will cover all levels from fundamental to applied science, highlighting the key role of lipids in neuronal functioning.
Maria Dolores Ledesma
Rik van der Kant
Session 31: Leveraging on translational prospective approaches to elucidate the biological signature of differential PTSD susceptibility
Chairs: Mirjam van Zuiden (Amsterdam) & Marloes Henckens (Nijmegen)
10-20% of trauma-exposed individuals develops posttraumatic stress disorder (PTSD). To develop effective preventive interventions for PTSD, it is pivotal to increase our understanding of neurobiological mechanisms underlying the differential susceptibility vs resiliency to PTSD by using translational prospective approaches. In this symposium we bring together recent findings of new experimental paradigms in rodents and humans with innovative clinical prospective approaches to share the latest developments in resilience research.
New York, NY, USA
16:00 Coffee-posters-actual poster presenting time
Session 32: Poster session 3
17:00 Plenary Session
Session 33: Keynote Lecture
Chair: Mark Verheijen (Amsterdam)
Los Angeles, CA, USA
Unmasking astrocyte contributions to neural circuit function
18:00 Closure DNM 21